Dr Shu graduated from Xiangya School of Medicine with PhD in Pathobiology (1999) and was then awarded a Wellcome Trust Travelling Fellowship to work at the University of Glasgow (1999-2001), where he worked on the human pathogen Paracoccidioides brasiliensis.
From July 2001, he moved to MRC Human Genetics Unit, to work as an Investigator Scientist (2001-2005) and then Senior Investigator Scientist, focusing on the disease mechanisms of retinitis pigmentosa (RP) and age-related macular degeneration (AMD).
In February 2010 he joined the Department of Life Sciences to continue his studies on the pathogenesis of retinal degeneration.